The primary focus of our laboratory is to understand how the brain encodes and stores information. We employ a multidisciplinary approach, combining observational and theoretical approaches to these questions. Using state of the art laser scanning microscopy we ‘film’ groups of neurons in the brain in action, allowing for the investigation of functional neuronal circuits. We enhance our imaging approach with electrophysiological and anatomical methods to better understand the components of these functional neuronal circuits. These data are analyzed using advanced statistical approaches and are also used to enhance neuronal network models. We move back and forth between experiment and theory in a complementary way in order to better understand fundamental principles which govern brain function.